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KMID : 0363320040250010001
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Journal of Korean Oriental Internal Medicine
2004 Volume.25 No. 1 p.1 ~ p.15
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Effects of Liriopis Tuber on Starvation Stress in Mice
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Jeon Sung-Ha
Baek Eun-Ki
Hong Yi-Sil
Park Jhee-Yoon
Han Jhee-Wan
Im Young-Nam
Go Ho-Yeon
Kim Dong-Woo
Jeon Chan-Yong
Park Jong-Hyung
Han Yang-Hee
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Abstract
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Objective : This study was aimed to evaluate the anti-starvation stress effect of Liriopis Tuber on mice.
Method : The first experiment was done to mice which have a high corticosterone level at a short term starvation. The plasma corticosterone level of each mouse was measured over time at 12, 24, 36, 48, 72 hours of starvation respectively. The second experiment was done in the two groups(LT A and LT B) of mice which were in famine for 36.5 hours after being administered Liriopis Tuber three times with different doses(LT A: 1.0 g/.kg and LT B: 3.0g/kg) for three days. The plasma corticosterone levels and rectal temperature were measured when a 36.5-hour of starvation period was finished.
Results :
1. The corticosterone level in the mice was significantly increased after a 36.5-hour of starvation. (P<0.001).
2. The plasma corticosterone level was decreased significantly in the group of 3.0g/kg, compared to the control group.(P<0.05)
3. The rectal temperature in the groups of 1.0g/kg and 3.0g/kg were increased slightly in both group. But the two groups didn’t show significant change.
Conclusion: Based on the above results, Liriopis Tuber might have anti-starvation stress effect and it may be used as anti-starvation stress medicine and anti-stress medicine.
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KEYWORD
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Liriopis Tuber, Starvation stress, Corticosterone
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